Andre Jean Festugiere (1898-1982) a ete directeur d'etudes a l'Ecole pratique des Hautes Etudes de 1943 a 1968. C'est pendant cette longue periode qu'il a donne une formidable impulsion, a Paris, aux etudes consacrees a l'Antiquite tardive Naturellement c'est aussi par ses publications nombreuses que le Pere Festugiere a contribue au rayonnement international de l'histoire de la philosophie a la fin du paganisme. On peut recenser 73 livres et 277 articles de revues et comptes rendus de livres. A la (...) fin de sa vie, il a reuni les plus importants de ses articles disperses en trois volumes. En 1971, ce furent les Etudes de philosophie grecque, en 1972, les Etudes de religion grecque et hellenistique et en 1975, les Etudes d'histoire et de philologie. Voici la reimpression des Etudes de philosophie grecque, qu'il a divisees en trois parties: d'abord les problemes generaux, puis les problemes de detail, enfin les Procliana. Les problemes de detail traitent ou bien de notions (eternite, endurance, peche) ou bien de questions particulieres posees par les ecrits de Platon, d'Aristote, de Theophraste, de Galien, d'Aristide Quintilien, ou d'expressions obscures dont le sens est devoile, tandis que les problemes generaux s'attaquent au probleme du mal, a celui du plaisir, aux rapports des philosophes grecs avec les sages orientaux et l'Inde, au systeme d'Aristote et aux genres de vie active et contemplative dans le monde greco-romain. Par la lecture de ces articles, le Pere Festugiere continue et continuera longtemps encore a enseigner ses lecteurs. (shrink)

L’esprit proprement religieux que l’on accorde à Platon à l’époque de la Renaissance ne se manifeste nulle part avec plus d’évidence que dans la conception de l’amour qu’entretiennent les poètes du XVIe siècle.Certes, le Moyen Âge avait célébré un amour spirituel, mais de l’amour il avait surtout établi le code, réglé la gestuelle et fixé le langage amoureux, issu des chansons courtoises. Or de cela les poètes renaissants ont tiré une philosophie qui rapporte la source de l’amour aux reflets de (...) la Beauté éternelle.Un philosophe le leur a appris : c’est Marsile Ficin qui, comme le démontre l’étude de A.-J. Festugière, fut le vrai promoteur dans toute l’Europe de cette religion platonicienne de l’amour. (shrink)

André Comte-Sponville livre ici vingt-six études d’histoire de la philosophie, portant principalement sur les traditions tragique et matérialiste, depuis l’Ecclésiaste jusqu’à Marcel Conche, en passant par Montaigne, Pascal, La Rochefoucauld, Spinoza, La Mettrie, Jean-Marie Guyau, Nietzsche et Alain. La préface propose une longue analyse de la notion de tragique. L’auteur y prend au sérieux ce que la littérature et la vie nous apprennent : que le tragique a à voir avec le malheur, mais réel plutôt que possible (...) (par différence avec le «suspense») et nécessaire plutôt que contingent (par différence avec le drame). Loin d’être l’affirmation joyeuse de tout, comme le voulait Nietzsche, le tragique est plutôt la prise en compte inconsolée de ce qu’il y a de catastrophique dans la condition humaine : la mort, la solitude, l’insatisfaction – trois formes de la finitude, qui ne sont tragiques que par la conscience, en l’homme, d’un infini au moins pensable. La conclusion, elle aussi fort développée, montre que le matérialisme, s’il est rigoureux, se doit d’être une pensée tragique, c’est-à-dire aporétique, déceptive, inconsolée. Et qu’une sagesse qui se sait insuffisante et insatisfaite (une sagesse tragique) vaut mieux, de ce point de vue, que la suffisance d’une sagesse prétendument satisfaite. Cela amène à prendre quelque distance avec Epicure, Spinoza, Nietzsche et Marx. Et à se trouver plus proche de Lucrèce, de Montaigne ou du dernier Althusser. (shrink)

In this paper, we examine recent critiques of the debate about defining disease, which claim that its use of conceptual analysis embeds the problematic assumption that the concept is classically structured. These critiques suggest, instead, developing plural stipulative definitions. Although we substantially agree with these critiques, we resist their implication that no general definition of “disease” is possible. We offer an alternative, inductive argument that disease cannot be classically defined and that the best explanation for this is that the concept (...) is structured as a cluster. We further argue that we do not need to reject the possibility of defining the general concept “disease” to legitimate developing stipulative definitions of disease that are relative to particular purposes. A cluster definition of disease is compatible with contextually motivated definitions, which may be considered précisifications of the more general cluster concept. (shrink)

We hypothesize that effective collaboration is facilitated when individuals and environmental components form a synergy where they work together and regulate one another to produce stable patterns of behavior, or regularity, as well as adaptively reorganize to form new behaviors, or irregularity. We tested this hypothesis in a study with 32 triads who collaboratively solved a challenging visual computer programming task for 20 min following an introductory warm‐up phase. Multidimensional recurrence quantification analysis was used to examine fine‐grained (i.e., every 10 (...) s) collective patterns of regularity across team members' speech rate, body movement, and team interaction with the shared user interface. We found that teams exhibited significant patterns of regularity as compared to shuffled baselines, but there were no systematic trends in regularity across time. We also found that periods of regularity were associated with a reduction in overall behavior. Notably, the production of irregular behavior predicted expert‐coded metrics of collaborative activity, such as teams' ability to construct shared knowledge and effectively negotiate and coordinate execution of solutions, net of overall behavioral production and behavioral self‐similarity. Our findings support the theory that groups can interact to form interpersonal synergies and indicate that information about system‐level dynamics is a viable way to understand and predict effective collaborative processes. (shrink)

Technological advances are making devices that functionally replace body parts—artificial organs and limbs—more widely used, and more capable of providing patients with lives that are close to “normal.” Some of the ethical issues this is likely to raise relate to how such prostheses are conceptualized. Prostheses are ambiguous between being inanimate objects and sharing in the status of human bodies—which already have an ambiguous status, as both objects and subjects. At the same time, the possibility of replacing body parts with (...) artificial objects puts pressure on the normative status typically accorded to human bodies, seemingly confirming that body parts are replaceable objects. The paper argues that bodies’ normative status relies on the relation of a body to a person and shows that persons could have similar relations to prostheses. This suggests that in approaching ethical issues surrounding prostheses, it is appropriate to regard them as more like body parts than like objects. (shrink)

This paper examines potential ethical and legal issues arising during the research, develop- ment and clinical use of a proposed strategy in personalized medicine (PM): using human induced pluripotent stem cell (iPSC)-derived tissue cultures as predictive models of individ- ual patients to inform treatment decisions. We focus on epilepsy treatment as a likely early application of this strategy, for which early-stage stage research is underway. In relation to the research process, we examine issues associated with biological samples; data; health; vulnerable (...) populations; neural organoids; and what level of accuracy justifies using the iPSC-derived neural tissue system. In relation to clinical use, we examine potential uses in pre-natal screening, and effects on clinical decision-making. Although our focus is providing recommendations for researchers developing work in this area, we identify the novel issue of deciding on an acceptable accuracy level for the system. We also emphasize an issue thus far neglected in the ethics of PM: PM tends to represent treatment decisions as though they should be directed solely by biomedical information, but this in itself could be detri- mental to best personalizing treatment decisions in the clinic. (shrink)

The ethical debate about neurotechnologies—including both drugs and implanted devices—has been largely framed around the questions of whether and when these technologies could damage or promote authenticity. Patients can experience changes in mood, behavior, emotion, or preferences—seemingly, changes in character or personality. Some describe such changes by saying they feel like different people; that they have become either more or less themselves; or that they feel as though some of their moods, behaviors, emotions or preferences are not their own. These (...) kinds of statements are used to describe both changes that a drug or device is... (shrink)

Personalised medicine has been discussed as a medical paradigm shift that will improve health while reducing inefficiency and waste. At the same time, it raises new practical, regulatory, and ethical challenges. In this paper, we examine PM strategies epistemologically in order to develop capacities to address these challenges, focusing on a recently proposed strategy for developing patient-specific models from induced pluripotent stem cells so as to make individualised treatment predictions. We compare this strategy to two main PM strategies—stratified medicine and (...) computational models. Drawing on epistemological work in the philosophy of medicine, we explain why these two methods, while powerful, are neither truly personalised nor, epistemologically speaking, novel strategies. Both are forms of correlational black box. We then argue that the iPSC models would count as a new kind of black box. They would not rely entirely on mechanistic knowledge, and they would utilise correlational evidence in a different way from other strategies—a way that would enable personalised predictions. In arguing that the iPSC models would present a novel method of gaining evidence for clinical practice, we provide an epistemic analysis that can help to inform the practical, regulatory, and ethical challenges of developing an iPSC system. (shrink)

Recently, concerns have been raised about the phenomenon of ‘overdiagnosis’, the diagnosis of a condition that is not causing harm, and will not come to cause harm. Along with practical, ethical, and scientific questions, overdiagnosis raises questions about our concept of disease. In this paper, we analyse overdiagnosis as an epistemic problem and show how it challenges many existing accounts of disease. In particular, it raises ques- tions about conceptual links drawn between disease and dysfunction, harm, and risk. We argue (...) that ‘disease’ should be considered a vague concept with a non-classical structure. On this view, overdiagnosed cases are ‘borderline’ cases of disease, falling in the zone between cases that are clearly disease, and cases that are clearly not disease. We then develop a pre ́cising definition of disease designed to provide practical help in preventing and limiting overdiagnosis. We argue that for this purpose, we can define disease as dysfunction that has a significant risk of causing severe harm to the patient. (shrink)

A basic principle of objectification theory is that a mere glance from a stranger represents the potential to be sexualized, triggering women to take on the perspective of others and become vigilant to their appearance. However, research has yet to document gendered gaze patterns in social groups. The present study examined visual attention in groups of varying gender composition to understand how gender and minority status influence gaze behavior. One hundred undergraduates enrolled in psychology courses were photographed, and an additional (...) 76 participants viewed groupings of these photographs while their point of gaze was recorded using a remote eye-tracking device. Participants were not told that their gaze was being recorded. Women were viewed more frequently and for longer periods of time than men in mixed-gender groups. Women were also more likely to be looked at first and last by observers. Men spent more time attending to pictures of women when fewer women were in the group. The opposite effect was found for pictures of men, such that male pictures were viewed less when fewer pictures of men were in the group. Female observers spent more time looking at men compared to male observers, and male observers spent more time looking at women than female observers, though both female and male observers looked at women more than men overall. Consistent with objectification theory, women’s appearance garners more attention and interest in mixed-gender social groups. (shrink)

Neil Levy argues that while addicts who believe they are not addicts are self-deceived, addicts who believe they are addicts are just as self-deceived. Such persons accept a false belief that their addictive behaviour involves a loss of control. This paper examines two implications of Levy's discussion: that accurate self-knowledge may be particularly difficult for addicts; and that an addict's self-deceived belief that they cannot control themselves may aid their attempts at self-control. I argue that the self-deceived beliefs of addicts (...) in denial and of self-described addicts differ in kind. Unlike the self-deception of an addict in denial, that of the self-described addict allows them to acknowledge their behaviour. As such, it may aid an addict to develop more self-control. A paradoxical implication is that this self-deception may allow an addict more self-knowledge. (shrink)

Community-based participatory research (CBPR) typically prioritizes community needs in the research process, attempting to link ethical and rigorous investigation with social action. However, balancing community needs and research goals can be challenging when working with marginalized communities in times of crisis. Strategies for engaging immigrant communities in CBPR is also underexplored in academic literature. This paper examines some of these challenges by focusing on a research project with immigrant homecare workers in Manitoba, Canada, who were disproportionately impacted by COVID-19, yet (...) largely excluded from government pandemic policy responses. The project aimed to explore these workers’ experiences and to contribute to migrant justice organizing through the research process. In this article, we present three interrelated tensions in our shifting research process: reflexive navigation of our research team members’ lived experiences and positionalities; community versus academic ethics; and timely responsiveness to shifting community priorities. We contribute to literature on CBPR with immigrant communities by articulating a reflexive migrant justice research approach amidst a crisis. This approach is developed through subversive relationship-building and intersectional solidarity with social justice community partners that disrupt dominant academic research processes. (shrink)

Evidence in medicine can come from more or less trustworthy sources and be produced by more or less reliable methods, and its interpretation can be disputed. As such, it can be unclear when disagreements in medicine result from different, but reasonable, interpretations of the available evidence and when they result from unreasonable refusals to consider legitimate evidence. In this article, we seek to show how assessments of the relevance and implications of evidence are typically affected by factors beyond that evidence (...) itself, such as our beliefs about the credibility of the speaker or source of the evidence. In evaluating evidence, there is thus a need for reflective awareness about why we accept or dismiss particular claims. (shrink)

Positive claims about narrative approaches to healthcare suggest they could have many benefits, including supporting person-centred healthcare (PCH). Narrative approaches have also been criticised, however, on both theoretical and practical grounds. In this paper we draw on epistemological work on narrative and knowledge to develop a conception of narrative that responds to these concerns. We make a case for understanding narratives as accounts of events in which the way each event is described as influenced by the ways other events in (...) the narrative are described. This view of narratives recognises that they can contribute knowledge of different kinds of connections between events: not just causal, and not just of patient’s perspectives. Additionally, narratives can add further epistemic value by suggesting potentially useful lines of inquiry. We take narrative approaches to healthcare to include clinicians considering both patients’ informational offerings and their own professional understandings as narratives. On this understanding, our account is able to overcome the major theoretical and practical criticisms that have been levelled against the use of narrative approaches in healthcare, and can help to explain why and how narrative approaches are consistent with PCH. (shrink)